This year’s Cape Cod summer symposia were the occasion for much discussion about important aspects of clinical practice. In this issue, we will describe and summarize some highlights of that discussion. One symposium was broad, and aimed at discussing diagnosis in detail, as well as the existential approach to psychiatry (“Becoming a master clinician: Drugs, diagnosis, and existential psychotherapy”). The second symposium was more focused on psychopharmacology, but aimed at the advanced clinician (“Psychopharmacology: A master class”). In this review, we’ll focus on a question that arose about how to conduct a diagnostic interview. The discussion on that question touches on important aspects of existential approaches to psychiatry as well.