Volume 1, Issue 2                                                                                      February, 2015

Special article: 

Antipsychotics (dopamine blockers) in bipolar depression 

There's more to it than FDA indications

FDA-indicted medications for acute bipolar depression are quetiapine (Serquel), olanzapine- fluoxetine combination (Symbyax, also called OFC), and most recently lurasidone (Latuda).  PL holds the view that two other medications, which do not have FDA indications, also have a scientific rationale for efficacy in bipolar depression.

Of these agents, quetiapine and OFC have, by far, the worst risks, especially if used long-term (given that they worsen metabolic syndrome and cardiovascular risks).  Thus, PL recommends ...

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