Volume 1, Issue 2                                                                                      February, 2015

Drug of the Month:  
Quetiapine (Seroquel)

Sedating, but not much of a dopamine blocker

Clinicians of a certain age will remember thioridazine (Mellaril).  At low doses, it made people tired and less anxious; at higher doses where it helped psychosis or mania, it knocked people out. But at least it wasn't a benzodiazepine, and it didn't have as much extrapyramidal side effects as other neuroleptic agents, especially at low doses. A much-searched holy grail of the benzodiazepine-like drug which doesn't addict. So clinicians loved it. Whether patients loved it is another question... 

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PL Reflection

Treatment is pruning a rose of its thorn.  

Jeffrey Gilbert MD

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