Classic Study of the month

Multimodal Treatment of ADD (MTA)

The longest randomized trial of amphetamines is misunderstood

This classic NIMH-funded study is the longest and largest randomized trial of the efficacy of amphetamines in childhood ADD.  It is cited widely as showing more benefit with those medications than with psychosocial interventions. In fact, this is not the case for functional outcomes. Further, the study provides important safety data which contradict other widely held beliefs; namely, it shows that substance abuse...

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William Gowers MD

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