Melancholic depression is characterized by typical depressive features but with marked anhedonia (lack of interest in all activities), no reactivity of mood (inability to feel better even briefly), and reversed diurnal variation in mood (feeling more depressed in the morning and better as the day progresses). Melancholia is usually conceptualized as a rather severe version of typical depression. This subtype responds better to TCAs than to SRIs, and often requires hospitalization. 

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