Drug of the Month:
Lamotrigine (Lamictal)

What doesn’t get you well keeps you well


Lamotrigine structure

Lamotrigine is an anticonvulsant which has turned about to be the latest, newest, proven effective “mood stabilizer,” by which PL means an agent which prevents mood episodes in bipolar illness.  The studies which proved lamotrigine’s efficacy were conducted over 15 years ago, and now the agent is available as a generic drug.

Clinical efficacy and inefficacy

In the late 1990s, when GlaxoSmithKline (GSK) was preparing its studies of lamotrigine, it had an ambitious agenda:  Multiple randomized clinical trials (RCTs) were conducted for acute mania, acute bipolar depression, and even acute unipolar depression.  Along with two studies in rapid-cycling bipolar illness, it added up to about a dozen randomized clinical trials. 

In all cases...

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Oliver Wendell Holmes Sr

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