Current study of the month:

Paroxetine in depression - A reanalysis 14 years later finds the truth wasn't told

Documentation of how companies “spin” randomized trials 


This is a disturbing study that isn't surprising. It took over 100,000 hours of work to get access to the actual data from a research study from 2001, conducted by Smith Kline Beecham (SKB)) on paroxetine for major depressive disorder (MDD) in children.    That published study reported benefit.  Over a decade later, a reanalysis with the same data reports no benefit. 

The difference partly is about...

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PL Reflection

How can you tell the difference between hypomania and normal happiness?  Hypomania is recurrent. Happiness is not.  

Hagop Akiskal MD

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