Curbside consults



Question:

Does quetiapine have any of the antidepressants' risks (for manic activation or rapid cycling) if used in the context of bipolar disorder, given its serotonin and other receptor profile?

The PL answer:

One way of answering this question is to infer that any medication that can elevate mood, i.e. improve depression, should also have some risk of causing mania, or cycling back-and-forth between mood episodes in the long term. It appears that some of the dopamine blockers that treat bipolar depression can...

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