Volume 1, Issue 2                                                                                      February, 2015


Study of the month

Symbyax dissected


When side effects masquerade as efficacy


The PL editor was once invited by Eli Lilly to present the main results of this OFC study at the annual meeting of the American Psychiatric Association. Speaking to a large audience, the PL editor noted that the “OFC” (olanzapine/fluoxetine combination) study was designed originally to prove efficacy of olanzapine alone, not OFC.  The study was powered statistically for that purpose:  370 subjects were randomized to olanzapine and 377 to placebo. Luckily for the manufacturer, a small sample of 86 subjects also was randomized to OFC...


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